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Wait until the gout attack stops to begin taking Colchicine/Probenecid , unless directed otherwise by your doctor. In a few studies colchicine-treated patients survived significantly longer than control patients {26} {27} {29} {31}. Although some studies have found that this action probably does not contribute significantly to colchicine's antigout action {08}, a recent in vitro study has shown that it may be at least partially involved {72}. Ask your health care provider if Colchicine/Probenecid may interact with other medicines that you take. Although colchicine may retard the development of fibrosis and hepatic failure in patients with biliary cirrhosis {32} {34}, it does not relieve symptoms {04} {26} {28} {31}, prevent or reverse histological changes characteristic of the disease {04} {26} {28} {29} {31}, or decrease the need for hepatic transplantation {32}. If you are already taking Colchicine/Probenecid , you may continue to take it during a gout attack unless your doctor tells you otherwise.
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